A manuscript record of pro-emperor insurrections in 1860s Kyoto (and possibly other cities). This manuscript is about some of the more infamous assassinations committed in Kyoto by anti-shogunate Imperial Loyalists during the Bakumatsu era (starting around 1862). Two of the illustrations in this manuscript are depictions of assassins Shimada Sakon and Méakashi Bunkichi.

There are only two possibilities for this manuscript:
1) It is a transcription of the 1864 text 三京珍説集, also called 三都珍説集, by the author 中村昭房, which only exists as a single manuscript held in the 狩野文庫 of Tohoku University. This text has been reprinted and analyzed in 史料京都見聞記, volume 5. In this case, your manuscript is one of only two existing copies in the world.

2) It is a completely unique manuscript in the world. This includes the possibility that it is an alternate version of 三都珍説集, since there is only a single copy of that one.
The title page has the title 三都珍説集, but the first page has the very curious alternate title 皇浪珍説論. This tells us that it is a record of pro-emperor insurrections in 1860s Kyoto (and possibly other cities), not Christianity.

The seal is very important on this one. Your manuscript seems to have belonged to a corporate library in the 1920s, now dissolved. It belonged to a private museum that sold off some of their holdings; the example shown in the link is at Kokubunken. They were foolish to sell such a unique item.

This is an archive of a manuscript volume and original photos of executions, including crucifixion, which came to Japan with Christianity. Together with the volume there are three original photographs of executions that took place in Yokohama, including that of the servant ‘Sokichi,’ who was crucified for killing his employer.